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determined that CUMS can lead to gut microbiota dysbiosis in rats and induce colonic inflammatory responses, including impaired gut barrier function and elevated pro-inflammatory cytokine levels (Wei et al., 2019)

Mario Vaisman, Federal University of Rio de Janeiro, Brazil Updates Copyright 2020 Lanzolla, Marcocci and Marin

A 2025 study published in JMIR Formative Research found that active subscribers on Second Natures GLP-1-supported programme lost an average of 19.1% of body weight at 12 months, with 77.7% achieving at least 10% weight loss

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